Figure!1:!Treatment!landscape!in!MZL!
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However,!for!a!significant!amount!of!patients!it!is!still!a!relapsing!disease!and!the!optimal!
diagnostic! and! therapeutic! approach! in! the! real! world! setting! is! still! a! matter! of! debate.!
Open!questions!in!MZL!are!summarized!in!Table!1.!
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Table!1:!Major!questions!in!MZL!
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Case!report! Open!questions!
IA,!IB! What!is!considered!to!be!the!appropriate!staging!procedure?!
II! What!is!the!role!of!PET/CT?!
IIIA,!IIIB,!IIIC! What!is!the!role!of!radiotherapy?!
What!is!the!best!irradiation!dose?!
Is!radiotherapy!alone!the!best!for!early!stage!disease?!
Should!we!combine!radiotherapy!with!other!compounds?!
IV! Is!an!individualized!therapy!possible?!
What!is!the!role!of!prognostic!scores!in!MZL?!
What!is!the!role!of!maintenance!therapy?!
Is!it!possible!to!prevent!early!relapse!(POD24)?!
V! What!is!the!role!of!target!therapy?!
Is!chemotherapy>free!therapy!possible?!
What!is!the!role!of!stem!cell!transplantation!(auto/allo)?!
What!is!the!role!of!CAR!T!cell!therapy?!