PIER(LUIGI(ZINZANI((BOLOGNA)(
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SALVAGE(TREATMENT(
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Case(2(–(Peripheral(T?Cell(Lymphoma(
This! is! the! story! of! a! 59>year>old! female! patient! affected! by! angioimmunoblastic! T>cell!
lymphoma,! diagnosed! in! 2010.! She! received! first>line! CHOP,! with! an! initial! response! at!
interim! PET! scan,! but! disease! progression! after! the! 4th! course,! with! fever! and! lactate!
dehydrogenase!elevation.!She!was!then!addressed!to!an!ifosfamide>containing!regimen!(IEV)!
followed! by! DHAP,! as! she! was! unable! to! mobilize! autologous! stem! cells! after! the! first! IEV!
course! because! of! febrile! neutropenia.! She! was! transplanted! with! PET! signs! of! residual!
disease! in! January! 2012.! Post>transplant! disease! reassessment! confirmed! new! abdominal!
lesions!and!a!significant!marrow!infiltrate.!
Lenalidomide! was! started! in! April! 2012.! An! HLA>matched! 10/10! marrow! unrelated! donor!
was!found.!!
A! negative! PET! scan! was! obtained! after! the! 4th! course! of! lenalidomide;! negative! bone!
marrow! was! seen! at! the! same! time.! She! was! allotransplanted! in! March! 2013,! achieving! a!
complete!response!(continuous!complete!response!after!7!years).!
!
References:(
Broccoli!A,!Argnani!L,!Zinzani!PL.!Peripheral!T>cell!lymphomas:!focusing!on!novel!agents!in!relapsed!
and!refractory!disease.!Cancer(Treat(Rev.!2017;!60:120>129.!
!
Broccoli! A,! Zinzani! PL.! Angioimmunoblastic! T>cell! lymphoma.! Hematol( Oncol( Clin( North( Am.! 2017;!
31(2):223>238.!
(
D’Amore!F,!et!al.!Up>front!autologous!stem>cell!transplantation!in!peripheral!T>cell!lymphoma:!NLG>
T>01.!J!Clin!Oncol,!2012;!30:!3093>3099.!
!
Morschhauser! F,! et! al.! A! phase! 2,! multicentre,! single>arm,! open>label! study! to! evaluate! the! safety!
and!efficacy!of!single>agent!lenalidomide!(Revlimid)!in!subjects!with!relapsed!or!refractory!peripheral!
T>cell!non>Hodgkin!lymphoma:!the!EXPECT!trial.(Eur(J(Cancer,!2013;!49:!2869>2876.!