TREATMENT'OUTCOMES'OF'LOCALIZED'STAGE'HODGKIN'LYMPHOMA'IN'
POSTER'29'
TUNISIA'
'
Raoudha!Mansouri1,!Dorra!Jabr1,!Karima!Kacem1,!Tarek!Ben!Ahmed2,!Rimel!Kanoun1,!Emna!Barred1,!
Meriem!Achour1,!Salma!Kefi1,!Manel!Bchir1,!Marwa!Bahri1,!Rachid!Kharrat1,!Hend!Ben!Neji1,!Yosr!Ben!
Abdennebi1,!Raihane!Ben!Lakhal1,!Lamia!Aissaoui1!and!Balkis!Meddeb1!
!
(1)Aziza!Othmana!Hospital,!TUNIS,!Tunisia,!(2)Farhad!Hached!Hospital,!Sousse,!Tunisia!
!
Introduction:'Since!2008,!the!Tunisian!protocol!for!the!treatment!of!localized!stage!Hodgkin!
lymphoma!(HL)!excluded!localized!forms!with!large!mediastinal!mass.!These!are!treated!with!
intensive!chemotherapy!such!as!escJBEACOPP!as!the!advanced!stages.!The!aim!of!this!work!
is! to! evaluate! this! new! strategy! adopted! according! to! the! 3! successive! versions! of! the! HL!
treatment! protocol.Patients' and' Methods:'142! patients! are! followed! in! the! clinical!
hematology! department! of! Aziza! Othmana! hospital! for! localized! stage! LH! (I! and! II)! and!
treated!according!to!the!3!national!protocols!MDH02,!MDH08!and!MDH15.!54!patients!were!
treated!according!to!MDH02,!88!patients!according!to!MDH08!and!41!patients!according!to!
MDH15.!The!assessment!is!based!on!whole!body!scan.!
Patients's'characteristics:!
! MDH02!
(54patients)!
MDH08!
(88)patients)!
MDH15!
(41patients)!
Age)median! 31ans)16E68! 28ans)16E75! 27ans)16E59!
Sex)ratio! 0.86! 0.76! 0.96!
IMT>0.35! 37%! 0! 0!
Bulky! 27.8%! 23.9%! 30%!
Stage)I!
0!
7.4)%!
10%!
II!
100%!
92.6%!
90%!
B)Signs! 20%! 41%! 27%!
Histologic)type)2!
81.5%!
81.8%!
84%!
3!
18.5%!
13.5%!
16%!
Inguinal)onset! 11.1%! 5.7%! 4%!
Therapeutic'results'and'survival'rates!
! MDH02! MDH08! MDH15!
CR+VGPR! 70.3%! 87%! 84%!
Primary)failure! 16.7%! 5%! 6%!
OS! 96%! 92%! 100%!