is!in!most!cases!treated!with!surgical!bilateral!removal!of!the!implants.!Dissemination!is!rare.!
Like!in!other!ALCL!subtypes,!mutations/upregulation!of!the!JAK>STAT!pathway!are!common.!
The! ALK>neg! ALCL! subtype! is! now! a! well>defined! entity! and! prognostically! relevant!
rearrangements,! particularly! affecting! the! DUSP22! (favorable)! and! the! TP63! (unfavorable)!
genes!have!been!recognized.!!
Possible! therapeutic! implications! of! these! and! other! molecular! findings! in! PTCL! will! be!
discussed! in! the! context! of! CD30>! (ECHELON>2! trial)! and! CD52>! (ACT>1! trial)>! directed!
therapy,!and!with!regard!to!the!role!of!transplant!in!PTCL.!
!
! !
