disease,!2!cycles!of!chemotherapy!plus!radiation!has!become!the!standard!of!care!for!these!
patients.! For! those! in! early! unfavorable! disease,! the! 2+2+RT! combination! is! currently!
standard!of!care.!For!those!in!advanced!stages,!BEACOPP!escalated!gives!15>20%!better!PFS!
and!10>15%!OS!but!is!associated!with!more!hemato>toxicity!and!infertility.!The!more!recent!
HD18!trial!demonstrated!that!4!cycles!of!BEACOPP!escalated!in!PET>negative!patients!gives!a!
tumor!control!of!nearly!95%!and!an!overall!survival!of!nearly!99%.!Other!combinations!such!
as! the! brentuximab! vedotin>AVD! combination! gave! poorer! outcomes! as! compared! with!
BEACOPP!escalated.!Interesting!new!combinations!based!on!checkpoint!inhibitors!seem!to!
be! very! effective! and! might! increasingly! replace! chemo>! and! radiotherapy! in! patients! with!
Hodgkin!lymphoma.!
With!this,!I!very!much!like!to!welcome!you!to!our!next!International!Symposium!on!Hodgkin!
Lymphoma!to!be!held!in!Cologne!between!October!22!and!24!in!the!year!2022.!