DOES'UPFRONT'AUTOLOGOUS'STEM'CELL'TRANSPLANT'AT'FIRST'RELAPSE'
IMPROVE'OUTCOME'IN'TRANSPLANT'ELIGIBLE'FOLLICULAR'LYMPHOMA'
POSTER'49'
PATIENTS'WHO'RELAPSE'WITHIN'24'MONTHS'
'
Ayel!Yahya1,!Osman!Radhwi2,!David!Macdonald2,!Lothar!Huebsch2!and!Mohamad!Sobh3!
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(1)University! of! ottawa,! Ottawa,! Canada,! (2)University! of! Ottawa,! Ottawa,! Canada,! (3)The! Ottawa!
hospital,!Ottawa,!Canada!
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In! Canadian! adults,! Follicular! lymphoma! (FL)! is! the! most! common! subtype! of!NonJHodgkin!
lymphomas!(NHL).Approximately!20%!of!patients!with!FL!experience!progression!of!disease!
(POD)! within! 2! years! of! first! line! chemoimmunotherapy.! Those! patients! have! an! expected!
overall! survival! of! less! than! 5!years.! The!optimal! secondJline! treatment! for! these! highJrisk!
patients! is! unclear.! We! analyzed! data! from!The!Blood! and!Bone!Marrow!Transplantation!
Center! at! the! Ottawa! Hospital! (TOH)! to! determine! whether! autologous! hematopoietic! cell!
transplant!(ASCT)!as!upfront!therapy!for!first!relapse!can!improve!outcomes!in!this!highJrisk!
FL! subgroup.! We! identified!17!patients! who! underwent!upfront!ASCT! between! February!
2012! and! February! 2019.! All! of! them! had! relapsed! within! 24! months! after! their! 1st!
RituximabJbased! chemotherapy.! The! OS! at! 2Jyear! and! 5Jyear!were!86.2%! (95%! CI:! 55J
96)!and!71.8%!(95%!CI:!31J91),!respectively.!The!PFS!at!2!year!and!5!year!was!62.6%!(95%!CI:!
35J81)!and!53.6%! (95%! CI:! 25J75),!respectively.! We! demonstrate! improved! OS! when!
receiving! autologous! hematopoietic! stem! cell! transplant! as! up! front! at! first! relapse! in!
transplant! eligible! follicular! lymphoma! who! relapse! within! 24! months! of! first! line! therapy.!
Considering!a!single!center,!the!result!looks!promising,!but!the!data!need!to!be!replicated!
with!a!larger!sample!size.!
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