Figure 2. The need for phlebotomies prior to and during treatment with PTG 300
First Dose Randomizatiotion
10
20 40 80 40 40
40 1
2
3
4
5
40
20
20
40
40
40
40
40
30
40 20 20
40 80 60
20 40 80
80 40 40 60
40 60
40
Weeks
6
7
8
9
10
11
12
13
14
15
16
17
Subject
Age/Sex
58/F
71/M
64/M
43/M
52/M
68/F
74/F
66/F
31/M
61/M
52/F
50/M
56/M
63/M
70/M
68/M
47/M
10
10
20
10
20
20
20
20
20
20
20
20
20
20
20
20
10 10
80 40
20 20
60
30
60
Blinded
-28 -20 -12 -4 0 8 12 16 20 24 28
PTG-300
History
Dose decision
Phlebotomy
18
Blinded
Blinded
Blinded
Blinded
Blinded
-24 -16 -8 4
60
40
65/M 20
