SCIENTIFIC PROGRAMME
SESSION I
BIOLOGY OF B-CELL
PRECURSOR ALL
SESSION II
BIOLOGY OF T-CELL ALL
SESSION III
MINIMAL RESIDUAL
DISEASE MONITORING
SESSION IV
INDIVIDUALIZED
MANAGEMENT OF ALL
SESSION V
NEW ADVANCES IN ALL
SESSION VI
CAR T-CELLS &
ALLOGENEIC HSCT
SESSION VII
FRONTLINE
INCORPORATION OF
BITES AND ADCS
SESSION VIII
T-CELL ALL AND
LYMPHOBLASTIC
LYMPHOMA
SESSION IX
PH AND PH-LIKE ALL
SELECTED ABSTRACTS
FOR AN ORAL
PRESENTATION
SELECTED ABSTRACTS
AS E-POSTERS
DISCLOSURES
ADOLFO FERRANDO (NEW YORK)
MOLECULAR MECHANISMS OF T-ALL
T cell acute lymphoblastic leukemia (T-ALL) is an aggressive hematological malignancy derived from
early T cell progenitors. In recent years genomic and transcriptomic studies have uncovered major
oncogenic and tumour suppressor pathways involved in T-ALL transformation and identified distinct
biological groups associated with prognosis. An increased understanding of T-ALL biology has already
translated into new prognostic biomarkers and improved animal models of leukemia and has opened
opportunities for the development of targeted therapies for the treatment of this disease.
Belver L, Ferrando A. The genetics and mechanisms of T cell acute lymphoblastic leukaemia. Nat Rev Cancer. 2016
Jul 25;16(8):494-507. doi: 10.1038/nrc.2016.63. PMID: 27451956.
Gianni F, Belver L, Ferrando A. The Genetics and Mechanisms of T-Cell Acute Lymphoblastic Leukemia. Cold Spring
Harb Perspect Med. 2020 Mar 2;10(3):a035246. doi: 10.1101/cshperspect.a035246. PMID: 31570389; PMCID:
PMC7050584.