LIONEL BLANC (NEW YORK)
ERYTHROID PROGENITORS
Despite the effective clinical use of steroids for the treatment of Diamond Blackfan anemia
(DBA), the mechanisms through which glucocorticoids regulate human erythropoiesis remain
poorly understood. In our recent studies we reported that the sensitivity of erythroid
differentiation to dexamethasone is dependent on the developmental origin of human CD34+
progenitor cells. In this presentation, we will discuss differences in the expansion of CD34+
cells after dexamethasone treatment and focus on the differences that exist in the erythroid
progenitor continuum between cord blood- and peripheral blood-derived hematopoietic
stem and progenitor cells. We will also present the role of p57kip2 in the mechanism of steroid
responsiveness and put these findings in the context of DBA in terms of steroid responsiveness
and transfusion-dependence.
Suggested Reading:
Yan, H., Hale, J., Jaffray, J., Li, J., Wang, Y., Huang, Y., An, X., Hillyer, C., Wang, N., Kinet, S., Taylor, N.,
Mohandas, N.*, Narla, A.*, Blanc, L.* (2018) Developmental Differences Between Neonatal and Adult
Human Erythropoiesis. Am. J. Hematol., Aug;93(4):494-503.
Ashley, R.J., Yan, H., Wang, N., Hale, J., Dulmovits, B. M., Papoin, J., Olive, M., E., Udeshi, N., D., Carr,
S. A., Vlachos, A., Lipton, J. M., Da Costa, L., Hillyer, C., Kinet, S., Taylor, N., Mohandas, N.*, Narla, A.*,
Blanc, L.* (2020). Steroid-resistance in Diamond Blackfan anemia associates with p57Kip2
dysregulation in erythroid progenitors. J. Clin. Invest., April 2020.
Blanc L. and Mohandas N. (2020). Resolving the Continuum of Human Erythroid Differentiation for the
Study of Ineffective Erythropoiesis in Erythroid Disorders, HemaSphere,