SCIENTIFIC PROGRAMME
SESSION I
THE GENOMIC AND
EPIGENOMIC LANDSCAPE
OF CLL AND CLINICAL
CONSEQUENCES
SESSION II
THE ROLE OF BCR
ACTIVATION AND
SIGNALLING FOR CLL
SESSION III
THERAPEUTIC OPTIONS
FOR CLL
SESSION IV
LONG TERM FOLLOW
UP OF CLINICAL TRIALS
VERSUS REAL WORLD
DATA (OUTSIDE CLINICAL
TRIALS DATA-OCT)
SESSION V
THE INCREASING ROLE
OF THE LEUKAEMIC
MICROENVIRONMENT
SESSION VI
THERAPEUTIC OPTIONS 2 :
THE USE OF CELLULAR
AND NON-CELLULAR
IMMUNOTHERAPIES IN
CLL
SESSION VII
EFFICACY THROUGH
SAFETY
SESSION VIII
CLONAL HETEROGENEITY,
CLONAL EVOLUTION AND
MECHANISMS OF DRUG
RESISTANCE
SESSION IX
CONTRASTING
THERAPEUTIC CONCEPTS
SELECTED ABSTRACTS
FOR AN ORAL
PRESENTATION
SELECTED ABSTRACTS
FOR A POSTER
PRESENTATION
FACULTY DISCLOSURES
Poster 22: THE INTERPLAY OF BCR SIGNALLING AND ADHESION CONTROLLED BY LIPID
PHOSPHATASES PTEN AND SHIP1
Michael Persicke, Peter Lichter, Stephan Stilgenbauer and Daniel Mertens
Poster 23: MONOCLONAL B CELLS OF CLL PHENOTYPE EXPRESS AN AUTONOMOUSLY
SIGNALING B-CELL RECEPTOR
Edwin Quinten, Kees van Bergen, Dietmar Pfeifer, Katja Zirlik, Ruben Groen,
Hassan Jumaa and Hendrik Veelken
Poster 24: SINGLE-CELL TRANSCRIPTOMIC ANALYSIS OF RESPONDERS AND NON-RESPONDERS
TO COMBINATION IBRUTINIB AND CART CELLS IN CHRONIC
LYMPHOCYTIC LEUKEMIA
Ruben Raychaudhuri, Maxim Shestov, David Porter and Saar Gill
Poster 25: ENERGY UTILISATION IN CHRONIC LYMPHOCYTIC LEUKAEMIA –
COMPARTMENTALISATION OF LIPID SCAVENGING AND STORAGE
Lauren Thurgood, Lara Escane, Giles Best, Karen Lower and Bryone Kuss
Poster 26: TARGETING TMEM176A ENHANCES VENETOCLAX-INDUCED APOPTOSIS
THROUGH INFLAMMASOME ACTIVATION IN LEUKEMIC CELLS
Angimar Uriepero, Florencia Rammauro, Marcela Vilarino, Daniel Prieto, Sofia
Russo, Mercedes Segovia, Maria Elena Marquez, Francine Bittencourt, Catalina
Berca, Victoria Remedi, Gimena Dos Santos, Marcelo Hill and Pablo Oppezzo
Poster 27: PTBP1 REGULATES ALTERNATIVE SPLICING OF APOPTOTIC PROTEIN:
IMPLICATIONS IN CLL AND IBRUTINIB RESISTANCE
Hua-Yuan Zhu, Xinqi Zheng, Xiaotong Li, Jue-jin Wang, Hanning Tan, Li Wang,
Wei Xu and Jian-Yong Li