Poster 15: SHANK1 AS A PREDICTIVE, DIAGNOSTIC AND PROGNOSTIC METHYLATION
BIOMARKER AND A POSSIBLE FUNCTIONAL PLAYER IN CHRONIC
LYMPHOCYTIC LEUKEMIA
Eleonora Loi, Loredana Moi, Antonio Fadda, Giannina Satta, Mariagrazia Zucca,
Sonia Sanna, Shadi Amini Nia, Giuseppina Cabras, Marina Padoan, Corrado
Magnani, Lucia Miligi, Sara Piro, Davide Gentilini, Maria Grazia Ennas, Melissa
C Southey, Graham G Giles, Nicole Wong Doo, Pierluigi Cocco and Patrizia
Zavattari
Poster 16: HISTONE VARIANT MACROH2A1 IS DOWNREGULATED UPON BTK
INHIBITION IN CHRONIC LYMPHOCYTIC LEUKAEMIA
Charlotte McDonald, Charalampos Xanthopoulos, Mark Catherwood, Ken Mills
and Efterpi Kostareli
Poster 17: IDENTIFICATION OF NEW PUTATIVE DRIVER MUTATIONS AND PREDICTORS
OF DISEASE EVOLUTION IN CHRONIC LYMPHOCYTIC LEUKEMIA
Adrián Mosquera Orgueira, Beatriz Antelo Rodriguez, Jose Angel Diaz Arias, Roi
Ferreiro Ferro, Paula Melero Valentin, Andrés Peleteiro Raindo, Miguel Cid
López and Jose Luis Bello Lopez
Poster 18: LOXO-305: A HIGHLY SELECTIVE AND NON-COVALENT BRUTON'S TYROSINE
KINASE INHIBITOR TARGETING IBRUTINIB-RESISTANT CLL
Aishath S Naeem, Winnie I Nguy, Svitlana Teykucheva, Stacey M Fernandes,
Vanessa Rai, Kevin Ebata, Eliana B Gomez, Barb J Brandhuber, Stephen M
Rothenberg and Jennifer R Brown
Poster 19: OVEREXPRESSION OF WILD-TYPE RRAS2 DRIVES B-CELL CHRONIC
LYMPHOCYTIC LEUKEMIA (B-CLL)
Clara L. Oeste, Alejandro M. Hortal, Claudia Cifuentes, Miguel Sánchez
Alcoceba, Marcos González Díaz, Balbino Alarcón
Poster 20: OVERCOMING VENETOCLAX RESISTANCE IN CLL BY ANTAGONISM OF
STROMAL TGF-Β MEDIATED DRUG RESISTANCE
Eugene Park, Jingyu Chen, Andrew Moore, Maurizio Mangolini, Alexander
Egle, Seth Frietze and Ingo Ringshausen
Poster 21: CO-OCCURRENCE OF BIALLELIC ATM AND TP53 ALTERATIONS IS RARELY
DETECTED IN CHRONIC LYMPHOCYTIC LEUKEMIA (CLL) AND RESULTS IN
DEFECTIVE MITOSIS IN CLL CRISPR/CAS9-GENERATED CELLULAR MODELS
Claudia Pérez-Carretero, Miguel Quijada-Álamo, María Hernández-Sánchez,
Ana E Rodríguez-Vicente, Ana Belén Herrero, Jesús-María Hernández-Sánchez,
Marta Martín-Izquierdo, Teresa González, Sandra Santos-Minguez, Cristina
Miguel-García, Jose-Angel Hernandez-Rivas, Rocío Benito, José-Luis Ordóñez
and Jesús María Hernández-Rivas